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Genotypes of the Helicobacter pylori vacA Signal Sequence Differ with Age in Korea
Author(s) -
Lee Jun Haeng,
Choe Yon Ho,
Jeon Byung Ha,
Oh Yoo Joung,
Kim Jae J.,
Rhee Jong Chul,
Kim Pum Soo,
Choi Mi Sook
Publication year - 2004
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/j.1083-4389.2004.00198.x
Subject(s) - genotype , genotyping , helicobacter pylori , medicine , biopsy , gastroenterology , polymerase chain reaction , biology , gene , genetics
Background. Studies on Helicobacter pylori genotypes have focused on adults in developed countries, and data on the genotypes of Helicobacter pylori recovered from the children are rare. Materials and methods. One hundred and twenty‐eight biopsy samples from patients with H. pylori infection were studied. The patients’ ages ranged from 9 to 83 years. PCR analysis for vacA genotypes was performed using DNA extracted from biopsy specimens. Results. Genotyping of the s‐region showed s1a in 33 (25.8%) samples and s1c in 82 (64.1%) samples. When the specimens were grouped by age, the distribution of s‐region genotype was found to be significantly different between groups ( p = .002). The prevalence of s1a was 45.2% in patients < 20 years old, but 14.9% in patients ≥ 50 years old. On the other hand, the prevalence of s1c or recombinant s1a‐s1c was higher in those ≥ 50 years old. The distribution of the m‐region did not differ significantly with age ( p = .110). Conclusions. Strain populations infecting Korean adults and children differ.