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An Advanced Wound Dressing with Superabsorbent, Microbicidal, and Hemostatic Properties
Author(s) -
Liesenfeld B.,
Toreki B.,
Batich C.,
Olderman G.,
Schultz G.
Publication year - 2008
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2005.130216al.x
Subject(s) - occlusive dressing , saline , hemostatic agent , wound dressing , bacterial growth , ammonium , dorsum , chemistry , surgery , wound healing , medicine , anesthesia , bacteria , materials science , hemostasis , biology , pathology , anatomy , organic chemistry , alternative medicine , composite material , genetics
Bacterial growth within extended use wound dressings remains a problem. We have developed a superabsorbent, microbicidal dressing based on the permanent attachment of a cationic polymer (the quaternary ammonium compound diallyl dimethyl ammonium chloride, DADMAC) onto a range of physical substrates. Treated gauze (Sof‐Wick™) absorbed 50x its weight in saline and reduced bacterial, viral and fungal growth by six logs in vitro (AATCC method 100), with no zone of inhibition or extractables, as shown in Figure 1 below. Bacterial kill occurs within minutes, and remains effective in 10% serum. Good hemostatic properties were demonstrated for treated gauze wound dressing using both a rat liver laceration model, and a renal artery transection model, showing equivalent efficacy to approved haemorrhage control dressings (Avitene, Surgicel, and Gel Foam) that do not claim microbicidal activity. Treated gauze passed cytotoxicity testing using rabbit eye and skin tests, as well as guinea pig dermal sensitization tests. 1Gauze sponges inoculated with E. Coli and stained for bacterial presence. Left is control; right is NIMBUS treated. Note no zone of inhibition around treated gauze.Acknowledgment: This research was supported by QuickMed Technologies.