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symposium i‐1. pathophysiology and treatment of pressure ulcer
Moderated by Koicki Hirata: The Study of Clinical Usefulness of Basic FGF
Author(s) -
Hamanoue Masahiro,
Nakajo Tetuhiro,
Kijima Fumio,
Nisijima Hiro,
Maenohara Sigeho
Publication year - 2005
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2005.130116z.x
Subject(s) - medicine , basic fibroblast growth factor , wound healing , neovascularization , staining , cd34 , surgery , fibroblast growth factor , necrosis , angiogenesis , pathology , growth factor , stem cell , biology , genetics , receptor
Recently, basic FGF (fibroblast growth factor) has been made clinical use for wound cure. We studied clinical usefulness of basic FGF. Cases: Nine cases took wound necrosis by infection. Two cases took burn after mastectomy. One case took abscess in pelvic space. Methods: We investigated healing rate of wound by healing area per day. And we evaluated histological wound healing by HE staining, labeling index of Ki64 staining, CD34 staining for index of neovascularization, and α‐smooth muscle actin staining for differentiation of fibroblasts. Result: Healing rate of nine cases with wound necrosis by infection was 5 cm 2 /day and that of two cases with burn after mastectomy was 0.5 cm 2 /day. Labeling index was more than 10%. CD34 staining showed increasing neovascularization of healing tissues with treatment of bFGF, compaired with that recieved other treatments. But the case with abscess did not recover and took the reoperation for treatment. Conclusion: We concluded that bFGF was efficacious against tissue damage and useful for wound cure. But basic FGF was not useful for the infectious focus without control.