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Disturbance of Wound Healing Affects the Defensive Mechanism at the Base of the Gastric Mucosa
Author(s) -
Yoshida Masashi,
Wakabayashi Go,
Ishikawa Hideki,
Shimazu Motohide,
Tanabe Minoru,
Kumai Koichiro,
Kubota Tetsuro,
Otani Yoshihide,
Saikawa Yoshiro,
Kameyama Kaori,
Kitajima Masaki
Publication year - 2005
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2005.130116d.x
Subject(s) - gastric mucosa , basal (medicine) , medicine , nitric oxide , in vivo , vascular endothelial growth factor , wound healing , pathology , gastroenterology , pharmacology , vegf receptors , stomach , immunology , biology , microbiology and biotechnology , insulin
In vivo microscopy was performed to observe the basal region after thermal injury to the back skin of rats. A donor of nitric oxide, 3‐morpholinosydnonimine hydrochloride (SIN‐1), or a serine protease inhibitor, camostat mesilate, was administered. Antivascular endothelial growth factor (VEGF) neutralizing antibody was administered 5 hours after thermal injury (anti‐VEGF group). Postcapillary venules could be observed in the basal region of the gastric mucosa (PV‐BGM). The PV‐BGM was dilated 5 hours after thermal injury, and it was reduced by the administration of SIN‐1 or pretreatment with camostat mesilate. In the control group, the erosions did not reach the basal region of the gastric mucosa. Most of the erosions healed within 72 hours. Delayed healing was observed in the anti‐VEGF group. In the anti‐VEGF group, exudation and congestion in the basal region was observed at 24 hours, and ulcer formation was observed at 72 hours after thermal injury. The blood flow of the PV‐BGM is thus speculated to increase when the mucosal superficial circulation is disturbed. The PV‐BGM can contribute to the defensive mechanisms in the basal region of gastric mucosa. The abnormal process of the healing may disturb the defensive mechanism at the base of the gastric mucosa, thereby result in ulcer formation.