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Modification of Wound Healing Process Using Basic Fibroblast Growth Factor
Author(s) -
Ono Ichiro,
Yamashita Toshiharu,
Tominaga Akihiro,
Akasaka Yoshiharu,
Ishii Toshiharu,
Jimbow Kowichi
Publication year - 2005
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2005.130116am.x
Subject(s) - medicine , basic fibroblast growth factor , wound healing , dermis , surgery , syringe , growth factor , pathology , receptor , psychiatry
In order to identify a means to reduce the scar formation of the skin after incision, this study examined the wound healing effect of bFGF in humans. BFGF was administered at dose of 0.1 and 1 μg per cm of sutured immediately after an operation. The drug was injected once into the dermis of the margins of wounds using a 27 G needle attached to a 1‐ml syringe to the patients. The lengths of the treated wounds varied from 1.5 cm to 23 cm, and the subjects were 2 to 76 years old. Sutured wounds after excision of skin tumors from the face, trunk and limbs and the sutured wounds such as those at the donor sites of full thickness skin grafts were treated with low dose bFGF injections. Postoperative administration of bFGF, inhibited scaring and accelerated healing without any serious side effects. Although double–blind studies are needed, we expect that so‐called scar‐less surgery may be possible by establishing of more sophisticated methods for administering bFGF and its combination with other drugs and/or gene therapy in the future.