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Open Wound Integrated Regenerative Therapy with Topical bFGF Trafermin for Deep Soft Tissue Defects with Bone Exposure
Author(s) -
Ohura N,
Ichioka S,
Asano T,
Nakatsuka T
Publication year - 2005
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2005.130116al.x
Subject(s) - medicine , granulation tissue , debridement (dental) , wound care , wound healing , soft tissue , surgery , exudate , negative pressure wound therapy , basic fibroblast growth factor , growth factor , pathology , alternative medicine , receptor
Aim: Recently advocated concept of wound bed preparation (WBP) has systematically concreted the critical components of wound care, including debridement, bacterial balance, and management of exudate. We succeed in experiences by topical pharmaceutical therapy combined with WBP. We aimed to demonstrate availability of the wound management. Methods: Since 1999, 18 exteriorized‐bone patients with deep soft tissue defects were treated with this treatment. Our procedure was composed of four steps; 1) Resection or debridement, 2) Wound cleansing (soaking foot and hand in the hot bath with antibacterial carbonated agent), 3) Topical medication: basic fibroblast growth factor (Trafermin; KAKEN, Tokyo) and bucladecine sodium (Actocin ointment; Daiichi Pharmaceu. Co. Ltd, Tokyo), and 4) Dressing. Results: The average time for whole coverage of the exposed‐bone area with healthy granulation was 23 ± 13( median;19, range; 7–47) days after surgical treatment (the 1 st step). The average time for complete epithelization was 72 ± 42 (55, 26–150) days in the patients who had not undergone skin graft. For minor amputations of diabetic feet the healing time until complete epithelization was 65 ± 46 (44, 26–150) days on an average. Conclusions: We concluded that the integrated approach mobilizing commercial available products for wound healing under optimally prepared environment offers advantage of facilitating the efficacy of exogenous therapeutic measures on condition that endogenous regeneration has been accelerated.