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Basic Fibroblast Growth Factor Accelerates Apoptosis in Acute Incisional Wound Healing and Reduces Scar Formation
Author(s) -
Akasaka Yoshikiyo,
Ono Ichiro,
Yamashita Toshiharu,
Jimbow Kowichi,
Ishii Toshiharu
Publication year - 2005
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2005.130116aj.x
Subject(s) - granulation tissue , apoptosis , wound healing , basic fibroblast growth factor , medicine , andrology , fibroblast , scar tissue , immunology , chemistry , growth factor , surgery , in vitro , receptor , biochemistry
Apoptosis has been shown to play an important role in the regulation of wound healing, and growth factors can mediate this process. In this study, we examined the relationship between the degree of healing and the level of apoptosis in full‐thickness‐incisional skin wounds, which were treated by conventional suturing with or without intradermal injection of bFGF (0.1 μg and 1 μg/cm of wound). The width of wound tissue showed that the degree of granulation formation in the 1 μg‐bFGF‐treated group significantly increased on day 7, whereas the degree of scar formation significantly decreased on days 14 and 28. Similarly, apoptotic cells significantly increased in the number on day 4 in the 1 μg‐bFGF‐treated group compared with that of the control group (p = 0.024), and decreased on days 14 and 28. These findings therefore, suggest that the accelerated apoptosis in the bFGF‐treated wounds contributes to the decreased cellularity in inflammatory change through elimination of cells with apoptosis, which resulted also in the reduction of scar formation. It therefore hypothesized that apoptosis is involved in the maturation of an acute wound into scar formation, and that bFGF can accelerate this process.