Premium
S‐IV‐04
A Vascularized Artificial Bone Graft Using the Periosteal Flap and Porous Hydroxyapatite; Basic Research and Preliminary Clinical Application
Author(s) -
Akiko Hirata M.D.,
Yu Maruyama M.D.,
Kiyoshi Onishi M.D.,
Akiteru Hayashi M.D.,
Michio Saze M.D.,
Emi Okada M.D.
Publication year - 2004
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2004.abstractl.x
Subject(s) - periosteum , neogenesis , medicine , artificial bone , mandible (arthropod mouthpart) , biomedical engineering , anatomy , surgery , biology , botany , islet , insulin , genus , endocrinology
Aim: Vascularized periosteum has an ability of new bone formation, and porous hydroxyapatite (HA) has an property of bone conduction. A basic research was performed to investigate the possibility of making a “hybrid” vascularized artificial bone from porous HA integrated with the vascularized periosteum. Materials & methods: A latissimus dorsi musculoperiosteal flap was raised in rabbit. In one group, HA blocks (porosity; 55%, dimension; 8 × 4 × 2 mm) were ligatened to the cambium layer of periosteum and muscle, and in the other group HA blocks combined with rhBMP‐2 were apllied in the same manner. HA blocks were removed 4, 8 and 12 weeks after the operation and were examined histologically. This method was applied preliminarily to 5 patients who needed bony repair of anterior chest, midface, and mandible. Results: Osteogenesis was observed within the pores of the blocks over the course of time. In rhBMP‐2 group, osteogenesis progressed rapidly to the same extent as in without rhBMP‐2 group. In clinical cases, postoperative bone scintigraphy demonstrated radioactive uptake into HA implants, and biopsy revealed bone neogenesis into the pores of HA. Conclusions: Our basic research and preliminary clinical applications suggested that the possibility of making the hybrid type of vascularized artificial bone preparation with HA using this method. This will enable less invasive procedure and custom‐made reconstruction without the need of vascularized autogeneous bone grafts.