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Clinical Trials of Allogenic Cultured Dermal Substitute for the Treatment of Burn Wounds
Author(s) -
Tadaaki Morotomi,
Hiroshi Kamiishi,
Kentaro Kubo,
Hiromichi Matsui,
Shizuko Kagawa,
Yoshimitsu Kuroyanagi
Publication year - 2004
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2004.abstractaq.x
Subject(s) - medicine , granulation tissue , burn wound , dermatology , surgery , granulation , clinical efficacy , wound healing , materials science , composite material
Aim: Recently, various types of cultured skin substitutes have been developed and some of them are used clinically. This study was designed to evaluate the efficacy of allogenic cultured dermal substitute which was applied to burn injuries in clinical trials such as deep dermal burns and dermal burns. Methods: Allogenic cultured dermal substitute (CDS) was simply applied to the burn wound, over which covering materials were applied to protect CDS. Results: The application of CDS to deep dermal burns was proved to facilitate healthy granulation tissue formation at early stage and epithelialization from the outer margins. When CDS applied to the debrided wound surface of dermal burns, an excellent wound bed was generated which was suitable for the graft take of an autologous patch. Conclusion: CDS provides an excellent epithelialization and granulation for burn wounds.