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Calcium‐Zinc Alginate and Recombinant Human bFGF; Its efficacy from the histological standpoint
Author(s) -
Otsuka T,
Tosa Y,
Hosaka Y
Publication year - 2004
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2004.abstractab.x
Subject(s) - granulation tissue , recombinant dna , zinc , granulation , calcium alginate , basic fibroblast growth factor , calcium , fibrosis , chemistry , wound healing , medicine , surgery , biochemistry , materials science , growth factor , receptor , organic chemistry , composite material , gene
Aim: To evaluate the efficacy of wound dressing material, Calcium‐Zinc Alginate: Curasorb Zn ® as a carrier of the recombinant human bFGF, histological detection was performed. Methods: Full thickness skin defect on the back of Wistar rat was made for four groups; the control group, bFGF group; topical application of recombinant human bFGF for 5 μg per day, Ca‐Zn Alginate group; topical use of the dressing and the group that both the bFGF and Ca‐Zn Alginate were applied, nine rats for respective group. Results: Significant granulation was noted both bFGF group and Ca‐Zn Alginate group compared to the control group. Fibrosis was noted in the control and Ca‐Zn Alginate group whereas no fibrosis was noted in the FGF group. Numerous amounts of cells were noted in the FGF group which indicate strong inflammation. Also, marked abscess formation was noted in the bFGF group. The greatest thickness of granulation was obtained in the group that both the bFGF and Ca‐Zn Alginate were applied. Conclusions: It was considered that the appropriate use of the carrier for the bFGF is important to control infection. The Ca‐Zn Alginate dressing was effective to suppress abscess formation.