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Effectiveness of Oasis ® Wound Matrix Versus Regranex ® in Treating Diabetic Wounds
Author(s) -
Niezgoda J. A.
Publication year - 2004
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2004.0abstractxt.x
Subject(s) - medicine , wound healing , wound care , debridement (dental) , surgery , diabetic foot , diabetes mellitus , chronic wound , clinical trial , interim analysis , randomized controlled trial , endocrinology
Background : Current care for chronic diabetic wounds involves maintaining wound hydration, providing protection from infection through regular dressing changes, and providing appropriate pressure relief. Even with the best care available, such therapies lead to effective wound healing in only 24% of ulcers within 12 weeks. Treatment of chronic ulcers with recombinant growth factors only moderately improves 12‐week healing rates, to 34%. A new, bioactive material, the Oasis ® Wound Matrix, comprises a full complement of structural extracellular matrix components and associated growth factors and may be more effective in managing chronic wounds than other current alternatives.
Method : Interim data from 88 evaluable patients in this multicenter, prospective, randomized clinical trial are presented. Patients diagnosed with chronic, full‐thickness, diabetic ulcers were enrolled and randomly assigned to receive either weekly treatments of Oasis Wound Matrix or daily treatments of Regranex ® becaplermin gel. All wounds were carefully cleaned and irrigated weekly for the duration of the study, with debridement performed as needed; wound areas were recorded to track the rate of wound closure. Incidence of complete wound healing by 12 weeks was evaluated.
Results : Study groups were balanced with respect to patient age and gender. Currently, 53%(24/45) of patients receiving Oasis wound matrix are considered healed versus 35%(15/43) of patients receiving treatment with Regranex.
Conclusion : These data clearly demonstrate Oasis wound matrix is at least as effective as becaplermin gel in managing chronic, full‐thickness, diabetic ulcers.