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Bone Marrow Mesenchymal Stem Cells as a Potential Source to Repair the Injury Skin
Author(s) -
Fu Xiaobing,
Fang Lijun,
Li Xiaokun,
Cheng Biao,
Sheng Zhiyong
Publication year - 2004
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2004.0abstractcd.x
Subject(s) - mesenchymal stem cell , stem cell transplantation for articular cartilage repair , bone marrow , endothelial stem cell , granulation tissue , stem cell , clinical uses of mesenchymal stem cells , pathology , skin repair , biology , microbiology and biotechnology , adult stem cell , wound healing , in vitro , medicine , immunology , biochemistry
Adult stem cells are found in various tissues and organs and have potential to differentiate into different cell lineages, including bone, cartilage, fat, tendon, muscle, epithelial cells of the skin and gastrointestinal tract, etc. Here, we report that the expended and purified bone marrow MSCs might take on phenotypes and characteristics of vascular endothelial cells or epidermal cells after cultured and induced with different lineage‐specific culture conditions in vitro. Also, in vivo grafting experiments confirmed that those labeled MSCs could get the phenotypes of vascular endothelial cells in granulation tissue and sebaceous duct cells and epidermal cells in regenerated skin, which imply that these grafted MSCs might have transdifferentiated into vascular endothelial cells and sebaceous duct cells and epidermal cells. Our results indicate that locally delivered bone marrow MSCs may generate de novo intact skin and get perfect skin regeneration after full thickness injury.