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The fibroblast‐populated collagen matrix as a model of wound healing: a review of the evidence
Author(s) -
Carlson Mark A.,
Longaker Michael T.
Publication year - 2004
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2004.012208.x
Subject(s) - wound healing , granulation tissue , fibroblast , contraction (grammar) , extracellular matrix , microbiology and biotechnology , matrix (chemical analysis) , in vitro , chemistry , medicine , surgery , biology , biochemistry , chromatography
The fibroblast‐populated collagen matrix (FPCM) has been utilized as an in vitro model of wound healing for more than 2 decades. It offers a reasonable approximation of the healing wound during the phases of established granulation tissue and early scar. The gross and microscopic morphology of the FPCM and the healing wound are similar at analogous phases. The processes of proliferation, survival/apoptosis, protein synthesis, and contraction act in similar directions in these two models, and the response to exogenous agents also is consistent between them. If its limitations are respected, then the FPCM can be used as a model of the healing wound. (WOUND REP REG 2004;12:–)