Quantitative trait loci affecting dengue midgut infection barriers in an advanced intercross line of  Aedes aegypti | Zendy

GomezMachorro C. | Zendy; Bennett K. E. | Zendy; Del Lourdes Munoz M. | Zendy; Black W. C. | Zendy

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Quantitative trait loci affecting dengue midgut infection barriers in an advanced intercross line of Aedes aegypti

Author(s) -

GomezMachorro C.,

Bennett K. E.,

Del Lourdes Munoz M.,

Black W. C.

Publication year - 2004

Publication title -

insect molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.955

H-Index - 93

eISSN - 1365-2583

pISSN - 0962-1075

DOI - 10.1111/j.0962-1075.2004.00522.x

Subject(s) - biology , quantitative trait locus , aedes aegypti , midgut , genetics , dengue fever , allele , genotype , phenotype , virology , gene , botany , larva

Quantitative trait loci (QTL) affecting the ability of the Aedes aegypti midgut to become infected with Dengue 2 virus (DEN2) were mapped in the F 5 generation of an advanced intercross line (AIL). A strain of Ae. aegypti previously selected for DEN2 susceptibility was crossed to a new strain selected for refractoriness to midgut infection. In P 1 and F 1 parents and 147 F 5 offspring, genotypes at forty‐four cDNA loci were analysed. A new sex linked QTL and a second QTL on chromosome II with genotypes subject to balancing selection were detected that condition midgut susceptibility. Alleles at these QTL contributed additively in determining susceptibility and accounted for ∼24% of the phenotypic variance. Markers associated with a midgut escape barrier were inconsistently supported.

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