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Metals and amyloid‐β in Alzheimer's disease
Author(s) -
Maynard Christa J.,
Bush Ashley I.,
Masters Colin L.,
Cappai Roberto,
Li QiaoXin
Publication year - 2005
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/j.0959-9673.2005.00434.x
Subject(s) - pathogenesis , homeostasis , genetically modified mouse , amyloid precursor protein , alzheimer's disease , amyloid (mycology) , downregulation and upregulation , clioquinol , microbiology and biotechnology , reactive oxygen species , chemistry , biology , neuroscience , transgene , disease , immunology , biochemistry , medicine , pathology , pharmacology , gene
Summary Mounting evidence is demonstrating roles for the amyloid precursor protein (APP) and its proteolytic product Aβ in metal homeostasis. Furthermore, aberrant metal homeostasis is observed in patients with Alzheimer's disease (AD), and this may contribute to AD pathogenesis, by enhancing the formation of reactive oxygen species and toxic Aβ oligomers and facilitating the formation of the hallmark amyloid deposits in AD brain. Indeed, zinc released from synaptic activity has been shown to induce parenchymal and cerebrovascular amyloid in transgenic mice. On the other hand, abnormal metabolism of APP and Aβ may impair brain metal homeostasis as part of the AD pathogenic process. Aβ and APP expression have both been shown to decrease brain copper (Cu) levels, whereas increasing brain Cu availability results in decreased levels of Aβ and amyloid plaque formation in transgenic mice. Lowering Cu concentrations can downregulate the transcription of APP , strengthening the hypothesis that APP and Aβ form part of the Cu homeostatic machinery in the brain. This is a complex pathway, and it appears that when the sensitive metal balance in the brain is sufficiently disrupted, it can lead to the self‐perpetuating pathogenesis of AD. Clinical trials are currently studying agents that can remedy abnormal Aβ–metal interactions.