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Regulation of growth signalling and cell cycle by Kaposi's sarcoma‐associated herpesvirus genes
Author(s) -
Direkze Shamindra,
Laman Heike
Publication year - 2004
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/j.0959-9673.2004.00407.x
Subject(s) - primary effusion lymphoma , kaposi's sarcoma associated herpesvirus , biology , cell growth , signal transduction , transcription factor , cell cycle , cancer research , microbiology and biotechnology , virology , cell , virus , immunology , gene , herpesviridae , genetics , viral disease
Summary Kaposi's sarcoma‐associated herpesvirus (KSHV) is the primary aetiological agent of at least three malignancies associated with HIV infection and immunosuppression: Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease. KSHV encodes proteins that deregulate key checkpoints in the signalling pathways governing cell proliferation, which may ultimately contribute to the virus' oncogenic potential. To alter cellular signalling associated with proliferation, these viral proteins function like growth factor ligands/receptors, signal transduction proteins, transcription factors and cell cycle regulators. This review focuses on the mechanisms by which some KSHV‐encoded proteins activate signalling pathways and cell proliferation and their role in the pathogenesis of KSHV‐driven mechanisms.