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Long‐Term Modulation By Postnatal Oxytocin of the α 2 ‐Adrenoceptor Agonist Binding Sites in Central Autonomic Regions and the Role of Prenatal Stress
Author(s) -
DíazCabiale Z.,
Olausson H.,
Sohlström A.,
Agnati L. F.,
Narváez J. A.,
UvnäsMoberg K.,
Fuxe K.
Publication year - 2004
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.0953-8194.2004.01146.x
Subject(s) - endocrinology , medicine , agonist , oxytocin , hypothalamus , amygdala , offspring , oxytocin receptor , receptor , alpha (finance) , biology , central nucleus of the amygdala , alpha 2 adrenergic receptor , chemistry , pregnancy , construct validity , genetics , nursing , patient satisfaction
The aim of this work was to evaluate whether oxytocin administered in male rats subcutaneously early in life in the absence or presence of food restriction during pregnancy has life‐long effects on the α 2 ‐agonist binding sites in the nucleus of the solitarii tract (NTS), in the hypothalamus and the amygdala, as evaluated by quantitative receptor autoradiography. Maternal food restriction alone increased the affinity of the α 2 ‐agonist [ 3 H]UK14.304 binding sites exclusively in the NTS. In offspring from ad libitum fed dams, oxytocin treatment significantly increased the density of α 2 ‐agonist binding sites in the NTS and in the hypothalamus. The K d value of the α 2 ‐agonist binding sites in the hypothalamus of these rats, but not in the other regions studied, was also significantly increased. In offspring from food‐restricted dams, oxytocin treatment produced a significant increase of the B max values in the hypothalamus and the amygdala and the K d value of the α 2 ‐agonist binding sites in the NTS of these rats also was selectively and significantly increased. These results suggest that a postnatal, oxytocin‐induced increase of regional α 2 ‐adrenoceptor function can be seen in adulthood by a persistent, regionally selective increase in the density of central α 2 ‐adrenoceptor agonist binding sites, in the absence of an affinity change in the NTS. Such a regional increase of α 2 ‐adrenoceptor signalling in adulthood may contribute to the anti‐stress action of postnatal oxytocin. By contrast, after prenatal stress, the potential increase in α 2 ‐adrenoceptor signalling takes place via selective increases of density with no changes of affinity of the α 2 ‐agonist binding sites in the hypothalamus and the amygdala.