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Hippocampal theta rhythm is reduced by suppression of the H‐current in septohippocampal GABAergic neurons
Author(s) -
Xu Changqing,
Datta Subimal,
Wu Min,
Alreja Meenakshi
Publication year - 2004
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.0953-816x.2004.03316.x
Subject(s) - hippocampal formation , neuroscience , gabaergic , hippocampus , diagonal band of broca , cholinergic , cholinergic neuron , psychology , inhibitory postsynaptic potential
Hippocampal learning and memory tasks are tightly coupled to the hippocampal theta rhythm, which is critically dependent on the medial septum/diagonal band of Broca (MSDB) although the underlying mechanisms remain unclear. The MSDB sends both cholinergic and GABAergic projections to the hippocampus. Here we show that: (i) septo‐hippocampal GABAergic but not cholinergic neurons have a pacemaking current, the H‐current, and that its selective blockade by ZD7288 reduces their spontaneous firing in rat brain slices; and (ii), local infusions of ZD7288 into the MSDB reduce exploration and sensory evoked hippocampal theta bursts in behaving rats. Thus, the H‐current in septohippocampal GABAergic neurons modulates the hippocampal theta rhythm.