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Gastric emptying of pancreatin granules and dietary lipids in pancreatic insufficiency.
Author(s) -
Norregaard P,
Lysgaard Madsen J,
Larsen S,
Worning H
Publication year - 1996
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.0953-0673.1996.00427.x
Subject(s) - gastric emptying , gastroenterology , pancreatitis , medicine , meal , exocrine pancreatic insufficiency , duodenum , breath test , stomach , endocrinology , helicobacter pylori
AIM: To investigate the emptying of enzyme granules and dietary lipids in patients with pancreatic insufficiency secondary to chronic pancreatitis. PATIENTS AND METHODS: Seven patients with chronic pancreatitis and exocrine pancreatic insufficiency ingested a test meal including colloidal 99m‐technetium‐radiolabelled liver pate, and swallowed two pancreatin capsules, in which half of the granules had been replaced with 111‐indium‐radiolabelled plastic particles of comparable physical dimensions. The passage of the two isotopes was followed simultaneously by gamma camera imaging for direct visual judgement and calculation of mean gastric emptying time. RESULTS: Pancreatin granules and dietary lipids were observed to empty simultaneously. In the duodenum the particles and the test meal were well mixed. Mean gastric emptying time of radiolabelled liver pate and radiolabelled plastic particles could be calculated in six patients. The median of these values were 47 and 43 min, respectively (P = 0.69). CONCLUSION: Pancreatin granules sized 1.0‐1.5 mm seem to empty together with dietary lipids.