Premium
Atomic force microscopy as an innovative tool for nanoanalysis of native stratum corneum
Author(s) -
Gorzelanny Christian,
Goerge Tobias,
Schnaeker EvaMaria,
Thomas Kai,
Luger Thomas A.,
Schneider Stefan W.
Publication year - 2006
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.0906-6705.2006.00424.x
Subject(s) - stratum corneum , atomic force microscopy , stripping (fiber) , microscopy , materials science , nanotechnology , beach morphodynamics , resolution (logic) , surface roughness , biophysics , nanometre , chemistry , optics , composite material , computer science , biology , pathology , medicine , physics , sediment transport , paleontology , artificial intelligence , sediment
This study demonstrates an innovative application of atomic force microscopy (AFM). The combination of high‐resolution AFM technology and tape stripping is presented as a tool for the structure analysis of human stratum corneum (SC) at a nanometer scale. Topographic images with a vertical resolution of about 10 nm of the SC are presented. Topographical and structural differences between aged and young skin can be observed. Aged skin SC is characterized by an increased single‐cell surface area, prominent intercellular gaps and enhanced cell surface roughness. The use of AFM in combination with other already established methods, e.g. tape stripping in the field of dermatological research will give new insights to the structure, function and morphodynamics of SC.