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Specific interleukin‐1 gene polymorphisms in Turkish patients with Behçet's disease
Author(s) -
Coskun Mesut,
Bacanli Ali,
Sallakci Nilgun,
Alpsoy Erkan,
Yavuzer Ugur,
Yegin Olcay
Publication year - 2005
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.0906-6705.2005.00253.x
Subject(s) - behcet's disease , genotype , allele , interleukin 1 receptor antagonist , pathogenesis , single nucleotide polymorphism , allele frequency , interleukin , immunology , polymorphism (computer science) , variable number tandem repeat , medicine , receptor antagonist , biology , cytokine , receptor , disease , antagonist , genetics , gene
Genetic factors that predispose individuals to Behçet's disease (BD) are considered to play important roles in the development of the disease. The pro‐inflammatory cytokine interleukin‐1 (IL‐1) has been implicated in the pathogenesis of BD. Our aim was to determine a possible association of specific polymorphisms of IL‐1α, IL‐1β, and IL‐1 receptor antagonist genes with susceptibility for BD. We genotyped 72 patients with BD and 163 healthy controls for IL‐1α−889, IL‐1β−511, and +3953 (nt5887) single‐nucleotide polymorphisms besides IL‐1 receptor antagonist variable number of tandem repeat polymorphism (for five different alleles). Comparison of the IL‐1β+3953 T allele and TT genotype frequencies showed a significant difference between patients with BD and controls (54.2 vs. 40.5%, OR = 1.74, P = 0.024, and 40.3 vs. 19.6%, OR = 2.76, P = 0.009, respectively). However, no difference was observed in the genotype or allele frequencies of IL‐1α−889, IL‐1β−511, and IL‐1 receptor antagonist between the patients with BD and the controls. Our results indicate that susceptibility to BD is increased in individuals carrying the IL‐1β+3953 T allele and TT genotype.