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A ‘hot’ new twist to hair biology – involvement of vanilloid receptor‐1 signaling in human hair growth control
Author(s) -
Bodó E.,
Bíró T.,
Telek A.,
Czifra G.,
Griger Z.,
Tóth I. B.,
Lázár J.,
Meschalchin A.,
Ito T.,
Bettermann A.,
Pertile P.,
Kovács L.,
Paus R.
Publication year - 2004
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.0906-6705.2004.212bd.x
Subject(s) - hair follicle , involucrin , outer root sheath , hacat , microbiology and biotechnology , capsaicin , downregulation and upregulation , keratinocyte , endocrinology , stimulation , trpv1 , biology , human skin , filaggrin , medicine , receptor , chemistry , cell culture , transient receptor potential channel , immunology , biochemistry , atopic dermatitis , gene , genetics
The functional role of VR1, which we and others have recently identified on several epithelial and mesenchymal human skin cell populations, was investigated in the human hair follicle (HF), as a prototypic epithelial–mesenchymal interaction system. VR1 immunoreactivity was confined to distinct epithelial compartments of HFs in anagen and catagen, while dermal papilla fibroblasts and HF melanocytes were VR1 negative. In organ culture, VR1 activation by capsaicin resulted in a dose‐dependent and VR1‐specific inhibition of hair shaft elongation, suppression of proliferation, promotion of apoptosis, and induction of catagen transformation, possibly due to upregulation of a potent hair growth inhibitor TGFβ2. Cultured outer root sheath (ORS), as well as HaCaT, keratinocytes also expressed functional VR1, whose stimulation inhibited proliferation, induced apoptosis, and elevated intracellular calcium concentration. Finally, VR1 stimulation of cultured ORS keratinocytes upregulated the expression of recognized endogenous hair growth inhibitors (IL‐1β and TGFβ2) and downregulated the expression of stimulators (HGF, IGF‐1, and SCF), while key differentiation markers (CK17, CK14, filaggrin, and involucrin) remained unaffected. In conclusion, VR1 is a significant novel player in human hair growth control underscoring that its physiological functions in human skin far extend beyond sensory neuron‐coupled nociception.