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Serum levels of manganese superoxide dismutase in patients with localized scleroderma
Author(s) -
Jinnin Masatoshi,
Ihn Hironobu,
Yazawa Norihito,
Asano Yoshihide,
Yamane Kenichi,
Tamaki Kunihiko
Publication year - 2004
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.0906-6705.2004.00160.x
Subject(s) - superoxide dismutase , scleroderma (fungus) , manganese , superoxide , medicine , reactive oxygen species , chemistry , dermatology , immunology , pathology , biochemistry , oxidative stress , enzyme , inoculation , organic chemistry
The objective was to determine the serum levels of manganese superoxide dismutase (Mn SOD) in patients with localized scleroderma and investigate their clinical significance in this disease. Serum samples from 15 patients with localized scleroderma and 20 healthy volunteers were examined by a specific enzyme‐linked immunosorbent assay. Serum levels of Mn SOD were significantly higher in patients with generalized morphea than those in healthy individuals. And the patients with elevated serum Mn SOD levels had significantly larger number of sclerotic lesions and significantly higher serum levels of soluble interleukin‐2 receptor than those without it. These results suggested that the serum levels of this enzyme may be a serological marker for the disease activity and the extent of skin involvement in this disease.