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Multiparameter Fiber Optic Sensor for the Assessment of Intramyocardial Perfusion
Author(s) -
Soller Babs R.,
Hsi Charles,
Favreau Janice,
Cingo Ndumiso,
Lancey Robert A.,
Okike Okike N.,
Vander Salm Thomas J.
Publication year - 2004
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.0886-0440.2004.04030.x
Subject(s) - medicine , circumflex , cardiology , occlusion , perfusion , anaerobic exercise , pco2 , artery , coronary occlusion , physiology
Objectives: The objective of this study was to characterize a multiparameter fiber optic sensor for detection of changes in intramyocardial perfusion and to demonstrate a method of determining critical values for pH, PCO 2 , and PO 2 to indicate onset of anaerobic metabolism. Methods: Six swine underwent a 20‐minute occlusion of the left anterior descending coronary artery (LAD). Myocardial pH, PCO 2 , and PO 2 were measured continuously in the LAD and left circumflex coronary artery (CFX) territories. Critical values for each parameter were calculated from these data. Results: During occlusion LAD myocardial pH declined from 7.36 ± 0.04 to 6.85 ± 0.04; PCO 2 rose from 57.0 ± 2.9 to 154.0 ± 18.0 torr, PO 2 fell from 78 ± 20 to 6 ± 5 torr. No myocardial pH or PCO 2 changes were observed in the CFX region, however, CFX PO 2 was affected in some animals during LAD occlusion and release. Methods for determining the ischemic threshold from these sensor data are presented. Conclusions: Multiparameter fiber optic sensors reliably respond to coronary occlusion and thus have the potential to help guide myocardial protection strategies for both on‐ and off‐pump cardiac surgery. (J Card Surg 2004;19:167‐174)