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CD1d‐restricted T‐cell subsets and dendritic cell function in autoimmunity
Author(s) -
Bollyky Paul L,
Wilson S Brian
Publication year - 2004
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/j.0818-9641.2004.01253.x
Subject(s) - cd1d , autoimmunity , biology , microbiology and biotechnology , immunology , mechanism (biology) , function (biology) , t cell , immune system , natural killer t cell , philosophy , epistemology
CD1‐restricted T cells have been shown to play a critical role in host defence, tumour surveillance, and maintenance of tolerance. However, immunologic outcomes resulting from activation of CD1d‐restricted T cells can be either beneficial or deleterious. A major mechanism by which CD1d‐restricted T cells are thought to exert immunoregulatory control is via effects on dendritic cell (DC) differentiation and migration. Important functional subsets of CD1d‐restricted T cells are also known to exist and the potential implications for preferential subset activations are discussed.