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Concomitant Vitiligo and Psoriasis in a Patient Treated with Interferon Alfa‐2a for Chronic Hepatitis B Infection
Author(s) -
Seçkin Deniz,
Durusoy Çiçek,
Şahin Sedef
Publication year - 2004
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.0736-8046.2004.21512.x
Subject(s) - medicine , vitiligo , psoriasis , concomitant , dermatology , chronic hepatitis , interferon alfa , interferon , alpha interferon , immunology , gastroenterology , virus
Abstract: Well‐known cutaneous side effects of interferon (IFN)‐alfa therapy include dry skin, pruritus, hair loss, and psoriasis. Presumably because of its potent immunomodulatory activity, the use of IFN‐alfa has also led to the development of autoimmune diseases in susceptible individuals. Vitiligo, an autoimmune cutaneous disease, has been reported to occur during IFN‐alfa therapy. We report a 10‐year‐old girl with chronic hepatitis B infection in whom IFN‐alfa treatment induced de novo development of vitiligo and psoriasis. Neither skin condition improved after withdrawal of interferon treatment. Concomitant occurrence of vitiligo and psoriasis due to IFN‐alfa has not been reported previously.