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HAEMOPOIETIC DEFECTS IN MICE INFECTED WITH LYMPHOCYTIC CHORIOMENINGITIS VIRUS
Author(s) -
BroJørgensen Klaus,
Volkert Mogens
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.0365-5563.1973.tb00010.x
Subject(s) - lymphocytic choriomeningitis , virus , biology , virology , inoculation , immune system , lethal dose , immunity , immunology , toxicology , cd8
Seemingly paradoxical observations were made with mice exposed to infections with the LCM virus and treatment with X‐rays. The X‐irradiation could afford a beneficial effect upon the cource of the viral infection or cause a serious aggravation. The beneficial effect was associated with X‐ray treatment given prior to the inoculation of virus. This pre‐irradiation effectively prevented an antiviral immune response and protected mice against lethal intracerebral challenges with the virus. However, doses of X‐rays which were sublethal for normal mice provoked a lethal disease when given to mice previously inoculated with the virus. Fatal outcomes were observed with persistent, tolerant virus carriers and with i. p. infected adult mice, that is, in cases of normally inapparent LCM virus infections. The X‐ray induced deaths were apparently not related to any enhanced growth of the virus in the irradiated mice. Clinical findings and reconstitution experiments strongly indicated that the striking increase in the sensitivity to X‐rays was caused by a haemopoietic defect in the LCM virus infected mice. The nature of this haemopoietic disorder is not readily explained. Thus several observations made it unlikely that the LCM virus had any direct damaging effect upon the haemopoietic cells. Moreover, the findings with the persistent, tolerant virus carriers provided evidence against any immunopathological basis of the disorder.