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Penile Cutaneous Metastasis of Prostate Adenocarcinoma: Report of a Case
Author(s) -
Iwenofu O.H.,
Sawh R.N.,
Pitha J.V.,
Lightfoot S.A.
Publication year - 2006
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2006.0511e.x
Subject(s) - medicine , pathology , adenocarcinoma , cytokeratin , metastasis , prostate , prostate cancer , malignancy , prostatic acid phosphatase , penis , prostatectomy , nodule (geology) , cancer , immunohistochemistry , anatomy , biology , paleontology
Adenocarcinoma of the prostate is the most common visceral malignancy in men and has a tendency to metastasize to the axial skeleton, lungs, adrenal, and liver. Cutaneous metastasis is extremely rare and portends resistance to therapy and poor prognosis. We report an unusual case of metastatic prostatic adenocarcinoma to the penile skin. A 77‐year‐old man presented with two‐month history of a subcutaneous nodule on the dorsal aspect of the glans penis in the region of the coronal ridge. The patient was seven years status‐post radical prostatectomy for adenocarcinoma of the prostate, and had previously received both radiation and hormonal therapy for metastatic bone disease. The penile nodule was excised and microscopic examination showed infilteration of the dermis by malignant acini exhibiting a cribriform growth pattern and central comedonecrosis. Immunohistochemical staining revealed that the tumor cells were negative for prostate specific antigen (PSA), thyroid transription factor‐1, cytokeratin 7, and cytokeratin 20, but were strongly and diffusely positive for prostatic acid phosphatase (PAP). Based on these findings, a diagnosis of metastatic prostatic adenocarcinoma was established. In addition to the unusual location on the penis, this case also demonstrates the importance of immunostaining for PAP when metastatic prostatic adenocarcinoma is suspected.