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CD30 + lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators
Author(s) -
Kempf Werner
Publication year - 2006
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2006.00548.x
Subject(s) - cd30 , lymphomatoid papulosis , lymphoproliferative disorders , pathology , anaplastic large cell lymphoma , lymphoma , medicine , pseudolymphoma , histopathology , differential diagnosis , large cell lymphoma
Summary: CD30 + lymphoproliferative disorders of the skin (CD30 + LPD) represent a well‐defined spectrum of primary cutaneous T‐cell lymphomas which have been recognized as distinct entities in recent lymphoma classifications. Lymphomatoid papulosis and anaplastic large‐cell lymphoma share the expression of CD30 antigen as a common phenotypic hallmark but differ in regard to their clinical and histologic features as well as their biologic behavior. This article summarizes the histologic features of CD30 + LPD and presents recently identified new clinicopathologic variants of CD30 + LPD. There is an increasing number of reactive inflammatory disorders and neoplastic diseases which are composed of or contain a significant number of CD30 + cells and mimic LyP or anaplastic large cell lymphoma clinically or histologically. Differential diagnostic considerations focus on other lymphoproliferative processes with CD30 + tumor cells as well as non‐lymphoid neoplasms and inflammatory simulators. The term CD30 + pseudolymphoma is proposed to designate inflammatory processes with CD30 + T cells. The final diagnosis of CD30 + LPD is based on a synthesis of clinical, histologic, phenotypic, and molecular genetic findings.