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Clear cell atypical fibroxanthoma – report of a case with review of the literature
Author(s) -
Murali Rajmohan,
Palfreeman Simon
Publication year - 2006
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2006.00427.x
Subject(s) - atypical fibroxanthoma , pathology , cd68 , clear cell , vimentin , cytokeratin , immunohistochemistry , histogenesis , cd99 , stroma , metaplastic carcinoma , nodule (geology) , biology , medicine , cancer , paleontology , breast cancer , genetics
Clear cell atypical fibroxanthoma (CCAFX) is a rare variant of atypical fibroxanthoma (AFX), a pleomorphic dermal tumour associated with a good prognosis. A 67‐year‐old man presented with a rapidly growing nodule on the ear, which had appeared over a 2‐week period. Sections showed an ulcerated nodule composed of pleomorphic spindled and polygonal cells with clear cytoplasm, invested by a delicate vascular stroma, reminiscent of clear cell renal cell carcinoma. Numerous mitotic figures were seen. The tumour cells stained with vimentin, CD68 and CD99 and were cytokeratin‐negative. The immunohistochemical and ultrastructural features supported a diagnosis of CCAFX. The diagnosis of CCAFX requires the exclusion of other pleomorphic clear cell tumours that can occur in the skin by using a combination of morphology, immunohistochemistry and electronmicroscopy.