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Ectopic hamartomatous thymoma: a case report with immunohistochemical study and review of the literature
Author(s) -
Kushida Yoshio,
Haba Reiji,
Kobayashi Shoji,
Ishikawa Masashi,
Doi Takashi,
Kadota Kyuichi
Publication year - 2006
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2006.00424.x
Subject(s) - cd99 , thymoma , pathology , desmin , cd34 , vimentin , synovial sarcoma , immunohistochemistry , keratin , sarcoma , medicine , anatomy , biology , stem cell , microbiology and biotechnology
Ectopic hamartomatous thymoma (EHT) is a rare benign tumor. We present a case of EHT, which was seen as subcutaneous mass on the left supraclavicular area in a 19‐year‐old man. The tumor consisted of spindle cells, epithelial cells, adipose cells, and a small amount of lymphocytes, as described previously. Immunohistochemically, spindle cells were positive for keratin, a‐smooth muscle actin, CD34 and vimentin, but negative for desmin and S‐100 protein. Lymphocytes were positive for CD45RO but negative for CD20, CD1a, and CD99. Approximately, 5% of cells were positive for MIB‐1 and no cells stained for p53 and bcl‐2. Recognition of EHT is important and needs to be differentiated from high‐grade sarcomas such as synovial sarcoma or glandular malignant peripheral nerve sheath tumor.