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Cutaneous mesenchymal hamartoma with mixed myogenous differentiation
Author(s) -
Schrecengost John Edwin,
Tabbara Sana,
Patterson James,
Wick Mark R.
Publication year - 2006
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2006.00414.x
Subject(s) - desmin , pathology , anatomy , lesion , dermis , submucosa , hamartoma , immunohistochemistry , skeletal muscle , medicine , biology , vimentin
A 3‐month‐old infant girl presented with a polypoid lesion in the perianal region. No changes in this lesion had been noted since birth. Microscopic examination of the excised specimen showed a mixture of mesenchymal elements, dominated by haphazard thin fascicles of skeletal muscle. Collagen and vascular changes were also apparent. Immunohistochemistry showed positive staining for muscle‐specific actin and desmin in the fascicular components of the lesion, and smooth muscle actin, desmin, and h‐caldesmon positivity in a haphazard collection of muscle fibers in the deep dermis and anal submucosa. Numerous Verhoeff‐van Gieson positive elastic fibers were also noted. Hamartomas containing skeletal muscle have rarely been reported outside of the head and neck region. They must be distinguished from a variety of other tumors, including juvenile rhabdomyoma, benign Triton tumor, and rhabdomyosarcoma.