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Multiple cellular neurothekeomas – a case report and review on the role of immunohistochemistry as a histologic adjunct
Author(s) -
Mahalingam M.,
Alter J. N.,
Bhawan J.
Publication year - 2006
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2006.00400.x
Subject(s) - pathology , vimentin , papule , immunohistochemistry , epithelioid cell , cd68 , stromal cell , medicine , desmin , head and neck , stroma , lesion , surgery
Background: Cellular neurothekeoma is a relatively rare, benign cutaneous neoplasm, which usually presents as a solitary papule or nodule involving the head and neck area of young adults. Multiple neurothekeomas have not, to date, been known to occur. Methods: We report a 30‐year‐old, otherwise healthy, male who presented with multiple neurothekeomas (15) in the head and neck area over a period of 12 years. Results: While the unifying feature of all biopsied (10 of 15) lesions was the presence of epithelioid cells – the lesions differed in their cellularity and the degree of sclerosis of the stromal component. Antigenic profiling of the lesional cells revealed expression of vimentin, NKI/C3, PGP 9.5, factor XIIIa and CD68 but not S100, HMB45, MelanA, EMA, MSA, desmin, CD57 or NGF‐R. Conclusions: This case report is the first to document the occurrence of multiple cellular neurothekeomas. An unusual histologic feature of some of the biopsied lesions was the presence of a markedly sclerotic stroma.