Premium
Hypertrophy of Pacinian Corpuscles in a Young Patient with Neurofibromatosis
Author(s) -
Yan Shaofeng,
Harris Brent T
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320hx.x
Subject(s) - medicine , neurofibroma , neurofibromatosis , anatomy , trunk , lesion , sensation , nerve sheath tumor , neurilemoma , pathology , schwannoma , biology , ecology , neuroscience
A 24‐year‐old female with a lifelong history of neurofibromatosis type 1 presented with left ring finger pain and decreased sensation for over a year. She has multiple café au lait spots over her entire trunk, upper and lower extremities. She also had 11 surgeries to excise superficial neurofibromas over her body. She first noticed a painful swelling of the proximal phalanx of the left ring finger. She then gradually noticed a loss of sensation distally and a constant numb and tingling feeling distal to the palm and the left ring finger. The clinical impression was neurofibroma. MRI of the tender lesion found no evidence of neurofibroma. Biopsy of the lesion showed hypertrophy of Pacinian Corpuscles. Hypertrophy of Pacinian Corpuscles is a rare condition which has been reported very infrequently. It should be considered in the differential diagnosis of any patient with persistent pain localized to the distal palm or digits in addition to glomus tumor and neuroma. It was thought not to be connected with neurofibromatosis. The finding of this lesion in a patient with neurofibromatosis is somewhat intriguing and the relationship of these two entities is unclear.