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Cutaneous and Systemic Plasmacytosis
Author(s) -
Wyatt AJ,
Salob S,
Klimek V,
Busam KJ
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320hw.x
Subject(s) - plasmacytosis , medicine , pathology , hypergammaglobulinemia , lymph , disease , bone marrow
Background: Plasmacytosis is a rare entity, which may manifest with cutaneous patches and plaques and may subsequently progress to involve extracutaneous sites. First described in Japan by Kimura K et al in 1983, most cases have been reported in patients of Asian descent. Observation: We report a case of plasmacytosis in a 52‐year‐old Hispanic woman, who presented ten years ago with cutaneous infiltrates of plasma cells and polyclonal hypergammaglobulinemia. Numerous (immunohistochemical, molecular, serologic) studies failed to demonstrate a clonal lymphoplasmacellular neoplasm, collagen vascular disease or chronic infection. Her course has been slowly progressive with new plaques developing on the integument. Plasma cells have since infiltrated gastric and esophageal mucosa, the left temporal artery and lymph nodes. The disease has been resistant to various therapeutic approaches. Conclusions: Our case provides long‐term follow‐up of a patient with plasmacytosis and illustrates the chronic progressive course of this disease over a 10‐year course with unique involvement of the temporal artery and gastrointestinal mucosa.