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Hyaline Cell‐Rich Chondroid Syringoma‐ Report of Two Cases.
Author(s) -
Veeramachaneni R.,
Sanusi I. D.,
Li M.
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320hl.x
Subject(s) - pathology , hyaline , myoepithelial cell , desmin , cytokeratin , vimentin , anatomy , sarcoma , biology , medicine , immunohistochemistry
Case 1: A 38 year‐old man presented with a painless right post auricular mass, slowly growing for ten years. Clinical impression was a salivary gland lesion. The excised mass measured 3 cm and was gelatinous. Case 2: A 28 year‐old man presented with a lump in the region of the left heel, slowly growing for several years. Excision revealed a lobulated pink‐gray mass measuring 2 cm. In both cases, histology demonstrated a circumscribed encapsulated proliferation of tumour cells surrounded by abundant myxoid stroma. There were almost exclusively hyaline cells with plasmacytoid features, arranged predominantly in nests and sheets with abundant pink cytoplasm and hyaline inclusions. Round to oval nuclei with occasional small nucleoli and rare mitotic figures were seen. Both cases stained strongly positive for low molecular weight cytokeratin, S 100 and vimentin and were negative for desmin, smooth‐muscle actin and muscle‐specific actin. We describe two cases of hyaline cell‐rich chondroid syringoma, a histologically benign entity. The importance in recognizing this entity is that these tumors can easily be confused with malignant neoplasms including malignant melanoma, myxoid chondrosarcoma and alveolar soft part sarcoma. Follow up for a year has shown no evidence of metastases or recurrence in both cases.