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Porokeratosis Causing Change in Melanocytic Nevi
Author(s) -
Thompson CT
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320hf.x
Subject(s) - reticular dermis , pathology , dermatology , porokeratosis , papillary dermis , medicine , parakeratosis , nevus , biopsy , dermis , melanocytic nevus , basal cell carcinoma , dyskeratosis , melanoma , hyperkeratosis , basal cell , cancer research
Porokeratosis is an uncommon cause of clinical change in pigmented lesions. We report two cases of so‐called “collision” lesions, in which the cause of clinical change in melanocytic nevi was porokeratosis. One biopsy was submitted concurrently with a biopsy from another anatomic site, which was a superficial pattern basal cell carcinoma. Both the melanocytic nevus and the basal cell carcinoma contained coronoid lamellae, focal diminution of the granular layer and subjacent dyskeratotic keratinocytes, consistent with disseminated superficial actinic porokeratosis (DSAP). The melanocytic nevus, from the lower back, was a broad compound melanocytic nevus, associated with elongated, pigmented rete (lentiginous) and small melanocytes in the papillary and superficial reticular dermis (superficial congenital pattern). There was no evidence of external irritation. The second case showed a similar coronoid lamella, focal diminution of the granular layer and dyskeratotic keratinocytes. There was additional parakeratosis away from the parakeratotic column and a lichenoid host response, suggesting external irritation.