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Atypical Lymphocytic Lobular Panniculitis in Korea: Frequent Expression of Epstein – Barr Virus
Author(s) -
Oh CW
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320fc.x
Subject(s) - medicine , vincristine , prednisone , lymphoma , cyclophosphamide , panniculitis , asymptomatic , pathology , chemotherapy
Although subcutaneous T‐cell lymphoma is considered an aggressive form of lymphoma, some patients manifest a long waxing and waning phase unaccompanied by constitutional symptoms. Magro et al (2004) applied the term “atypical lymphocytic lobular panniculitis (ALLP)” to this distinctive form of lymphocytic panniculitis. Eight ALLP patients (five females and three males, mean age: 34.0 ± 12.5) were encountered from Jun 1999 to Nov 2003 at GyeongSang National University Hospital in Korea. Five patients (62.5%) had skin lesions only and oral prednisone therapies were done. Two of five had no relapse but three showed a waxing and waning course till now. In three patients (37.5%) presenting cytopenias and fevers, chemotherapies were done with prednisone, cyclophosphamide, vincristine, doxorubicine, bleomycin and/or adriamycin. Two of three led to complete resolution till now and included only one patient with clonal T‐cell receptor‐gamma rearrangements. In seven patients, serum EBV antibody studies were performed. Six of them suggested EBV reactivation state and one was asymptomatic EBV carrier. In three patients, tissues EBV ISH were done and all were positive to EBER and lytic probe.