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Nodular Hidradenoma Arising in a Nevus Sebaceus of Jadassohn
Author(s) -
Michael Magill J.,
Jain Sima M.,
Devore Amy,
Chin Gloria,
Hassanein Ashraf M.
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320ej.x
Subject(s) - hamartoma , apocrine , pathology , nevus , anatomy , scalp , sebaceous gland , hidradenoma , medicine , biology , melanoma , cancer research
Nevus sebaceous of Jadassohn, a cutaneous hamartoma, results from disordered development of epidermal, follicular, sebaceous and apocrine differentiation that typically appears as a yellow verrucous plaque on the scalp or face. We present a 36‐year‐old white male with a congenital, nodular lesion along the hairline of his forehead, which had been traumatized repeatedly during hair grooming. Clinically, it was a well‐demarcated, curvilinear, erythematous, non‐tender plaque with no umbilication, ulceration or discharge. The periphery had a circumferential tan‐yellow, raised, waxy serpiginous border. Microscopically, the specimen had epidermal papillomatous hyperplasia with dilated infundibula of irregular mature sebaceous lobules, and mid‐dermal apocrine gland lobules. Within the hamartoma, was a well‐circumscribed, multi‐lobulated dermal tumor with epidermal and follicular attachments, focal ductal differentiation and cystic changes. Two distinct cell types were present; in the center were large polyhedral cells with focal clear cytoplasm, and at the periphery were spindle‐shaped cells with basophilic cytoplasm. These findings were typical of nodular hidradenoma arising within a nevus sebaceous of Jadassohn, a rare event with only seven cases previously documented in the literature.