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Epithelioid Cell Histiocytoma with Granular Cells
Author(s) -
Lee J.
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320dy.x
Subject(s) - vimentin , cd68 , pathology , epithelioid cell , s100 protein , cytoplasm , desmin , granular cell tumor , giant cell , immunostaining , immunohistochemistry , medicine , biology , microbiology and biotechnology
Epithelioid cell histiocytoma (ECH) is regarded as a variant of fibrous histiocytoma. It is not readily recognized as fibrous histiocytoma because of its unconventional histologic features and its resemblance to Spitz nevus. The ECH reported herein was from a 50‐year‐old man who presented with an asymptomatic, 1.5 cm, polypoid mass of unknown duration on his posterior shoulder. Histologic examination revealed epidermal collarette and dermal sheets of epithelioid cells with granular cytoplasm. Both fine and coarse granules were noted in the cytoplasm. They were PAS positive and diastase resistant. Many dilated vessels were also noted in the lesion. A panel of immunostains including S100, vimentin, CD68, and factor 13A was done. The lesional cells were reactive with vimentin, CD68, and factor 13A, and non‐reactive with S100. These results favored exclusion of Spitz nevus and granular cell tumor, and supported the histologic impression of ECH. Both fine and coarse cytoplasmic granules were reactive with CD68. The latter finding supports that the cytoplasmic granules in this ECH represent lysosomes as in granular cell tumors.