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A Case of Malignant Melanoma with Multiple Primary Lesions
Author(s) -
Kato M.,
Taguchi M.,
Kuramochi A.,
Suzuki T.,
Tsuchida T.
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320dk.x
Subject(s) - melanoma , medicine , autopsy , lesion , dissection (medical) , pathology , trunk , stage (stratigraphy) , superficial spreading melanoma , cancer , dermatology , radiology , biology , ecology , paleontology , cancer research
A 49‐year‐old Japanese male first visited our clinic at May 13th, 2003. A bean‐sized black macule had been noticed in the parietal region since childhood. The lesion had increased in size gradually and had become 30 mm in diameter. The lesion was diagnosed as malignant melanoma clinically and also dermoscopically. Sentinel node navigation using radioisotope revealed the metastases. We performed wide local excision and radical neck dissection, and the definite diagnosis of malignant melanoma and regional nodal metastases was made. TNM staging was stage?b, that is, pT4b, N2c, M0. The patient also had nine small black freckles on the trunk and extremities. All of them were excised, and eight lesions of them were diagnosed as malignant melanoma, because proliferation of atypical melanocytes and formation of abundant abnormal nests in epidermis were observed histopathologically. Chemotherapy was performed, but metastases of skin and visceral region were found in February, 2004. These lesions had put up strong resistance to chemotherapy and the patient died on June, 6th, 2004. Autopsy revealed multiple metastases including heart, kidneys, liver and large intestine and so on. No other family members suffered from malignant melanoma. The origin of this patient’s melanoma remained unclear.