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Chronology of Cellular Blue Nevus
Author(s) -
Jin L.,
Arai E.,
Tsuchida T.,
Ogawa F.,
Mitsuhashi T.,
Ban S.,
Shimizu Y.,
Hirose T.,
Shimizu M.
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320di.x
Subject(s) - blue nevus , dermis , pathology , nevus , nodule (geology) , epithelioid cell , anatomy , biology , medicine , melanoma , immunohistochemistry , paleontology , genetics
Cellular blue nevus is composed of dendritic melanocytes, together with islands of epithelioid and plump spindle cells. We examined 58 cases of blue nevi. Fourteen cases were common blue nevi. The remaining 44 blue nevi were divided into three types according to its silhouettes. These were nodular (type 1, 18 cases), nodular with notch (type 2, 16 cases), and rounded pushing patterns (type 3, 10 cases). Well circumscribed top heavy nodule was observed in type 1, and it was limited to the dermis. Type 2 showed budding appearance into the subcutaneous tissue. Type 3 revealed bottom heavy with downward pushing margin. Both type 2 and type 3 were demonstrated biphasic patterns of epithelioid and spindle cells. Perineural distribution of melanocytes was also observed in type 2 and 3. The size of these types was 3.3 mm in type 1, 4.7 mm in type 2, and 7.4 mm in type 3. The thickness of these types was 1.6 mm in type 1, 2.5 mm in type 2, and 5.2 mm in type 3. Our results suggest that cellular blue nevi may be divided into three stages. Type 1 is its early stage, and may be misinterpreted as common blue nevi.