Premium
Interstitial Granulomatous Dermatitis with Plaques
Author(s) -
Farmer AJ,
Wang LC,
Medenica MM
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320bu.x
Subject(s) - pathology , histiocyte , giant cell , medicine , immunoglobulin d , histopathology , dermis , sacrum , anatomy , antibody , immunology , b cell
A 74‐year‐old woman presented with an asymptomatic, 20 by 10 cm, erythematous, indurated plaque on the sacrum with similar lesions in the folds of both legs. Laboratory studies revealed an elevated ANA and ESR but normal rheumatoid factor, TSH, Lyme, anti‐DNA, and SSA/SSB antibodies. Biopsies from the sacrum and left leg showed a perivascular and interstitial infiltrate of foamy histiocytes, epitheliod cells, and multinucleated giant cells, as well as lymphocytes and eosinophils in the entire dermis. The patient was diagnosed with interstitial granulomatous dermatitis (IGD) with plaques. The lesions resolved spontaneously. IGD with plaques is a rare but benign disorder of uncertain etiology. Its characteristic histopathology and clinical appearance distinguish it from other granulomatous dermatitis.