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Non‐Neural Granular Cell Tumour: A Clinicopathological Review of 11 Cases
Author(s) -
Chaudhry I.H.,
Calonje E.
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320ao.x
Subject(s) - pathology , immunohistochemistry , s100 protein , cd68 , cytokeratin , nuclear atypia , atypia , medicine , neoplasm
Cutaneous granular cell tumour is a well‐characterised benign neoplasm of Schwann cell origin. However, there remains a sub‐category of neoplasms that appears non‐neural in origin and thus requires further appraisal. We present on 11 clinicopathological cases of non‐neural granular cell tumour, highlighting the histological patterns, immuno‐profile, clinical features and behaviour. The results showed that lesions most commonly occurred in young to middle aged adults (9 cases, median = 33 years, age range: 6–56 years), with a slight female predominance. The lesions presented as painless nodules, mainly on the extremities or face. Local excision was the treatment of choice and up to date follow‐up reveals no local recurrence or metastasis. Histologically, the lesions were polypoid (8 cases) or intra‐dermal (3 cases), and composed of elongated spindle‐shaped to polygonal cells with prominent granular cell change and focal, variable nuclear atypia. Low level of mitotic activity was noted. Immunohistochemical labelling of the tumour cells showed expression for NKI‐C3 (n.11) and CD68, with no staining for S100 protein, SMA, desmin and cytokeratin. In conclusion, this analysis of 11 clinicopathological cases will contribute to the characterisation of this recently described entity, which despite some atypical histological features appears to behave in a completely indolent fashion.