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Aggressive Basaloid Carcinoma with Pilo‐Sebaceous Differentiation of the Head and Neck: Report of Six Cases
Author(s) -
Centurion S. A.,
Baisre A.,
Mirani N.,
Baredes S.,
Turbin R.,
Langer P. D.,
Lambert W. C.
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.320al.x
Subject(s) - medicine , enucleation , pathology , sebaceous gland , neoplasm , sebaceous carcinoma , basal cell carcinoma , carcinoma , hair follicle , basal cell , surgery
We report six cases of a basaloid neoplasm arising on the head and neck showing immature sebaceous gland and focal immature hair follicle differentiation. Four cases arose in the periorbital area, one on the lower lip, and one on the neck. In all six cases extensive involvement of the surrounding soft tissues was observed. In five cases the tumor involved and was particularly aggressive in bone, requiring extensive resection. In two cases tumor extended to and involved the dura mater of the brain. Three cases required enucleation. Patients ranged in age from 30 to 81 years and consisted of four males and two females. No infection, syndrome, or other predisposing factor was known to be present. No patient was known to be a smoker or to engage in any other risk activity for cancer. No evidence of metastasis was noted in any patient. We conclude that the basaloid neoplasm showing immature pilo‐sebaceous differentiation of the head and neck is a distinct entity with a much more aggressive course than basal cell carcinoma and a different progression from that of any other adnexal neoplasm, including sebaceous carcinoma.