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D2–40 Expression in Hemangiomas and Lymphangiomas: Special Reference to its Differential Utility Between Kaposiform Hemangioendothelioma and Acquired Tufted Angioma
Author(s) -
Arai E.,
Kuramochi A.,
Shimizu M.,
Hirose T.
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.0320l.x
Subject(s) - pathology , lymphangioma , cd31 , capillary hemangioma , hemangioendothelioma , medicine , hemangioma , cd34 , lymphatic system , angioma , hemangiosarcoma , epithelioid hemangioendothelioma , angiosarcoma , lymphatic endothelium , immunohistochemistry , vascular disease , biology , stem cell , genetics
Recent investigations have demonstrated the utility of D2–40 as a marker for lymphatic endothelium and can be used for formalin‐fixed and paraffin‐embedded materials. We studied 13 capillary hemangiomas: kaposiform hemangioendothelioma (KH, 2), acquired tufted angioma (ATA, 5), juvenile hemangioma (JH, 2), granuloma pyogenicum (GP, 4); 6 other hemangiomas: cavernous hemangioma (3), arterio‐venous hemangioma (1), angiokeratoma (1), epithelioid hemangioma (1); Kaposi’s sarcoma (1); 12 lymphangiomas: lymphangioma circumscriptum (6), deep type of cutaneous lymphangioma (6). D2–40 monoclonal antibody, endothelial markers (CD31, CD34, Factor VIII related antigen) and juvenile hemangioma‐associated marker GLUT‐1 were applied. D2–40 was immunopositive for the peripheral area of proliferative capillaries and negative for surrounding dilated vessels in KH, but positive for surrounding dilated vessels and negative for tufted proliferative capillaries in ATA. KH and ATA were all positive for endothelial markers and negative for GLUT‐1. Other hemangiomas were negative for D2–40. Eight of 12 cases were positive for lymphangiomas. Based on these results, D2–40 is a useful additional immunostain for the discrimination of KH and ATA. KH and ATA may originate from different stage of both the lymphatic and blood vessel endothelial lineages.