Premium
WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects
Author(s) -
Burg Günter,
Kempf Werner,
Cozzio Antonio,
Feit Josef,
Willemze Rein,
S. Jaffe Elaine,
Dummer Reinhard,
Berti Emilio,
Cerroni Lorenzo,
Chimenti Sergio,
DiazPerez José L.,
Grange Florent,
Harris Nancy L.,
Kazakov Dmitry V.,
Kerl Helmut,
Kurrer Michael,
Knobler Robert,
Meijer Chris J.L.M.,
Pimpinelli Nicola,
Ralfkiaer Elisabeth,
RussellJones Robin,
Sander Christian,
Santucci Marco,
Sterry Wolfram,
Swerdlow Steven H.,
Vermeer Maarten H.,
Wechsler Janine,
Whittaker Sean
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.00495.x
Subject(s) - lymphoproliferative disorders , context (archaeology) , pathology , lymphoma , medicine , biology , paleontology
The new WHO/EORTC classification for cutaneous lymphomas comprises mature T‐cell and natural killer (NK)‐cell neoplasms, mature B‐cell neoplasms, and immature hematopoietic malignancies. It reflects the unique features of lymphoproliferative diseases of the skin, and at the same time it is as compatible as possible with the concepts underlying the WHO classification for nodal lymphomas and the EORTC classification of cutaneous lymphomas. This article reviews the histological, phenotypical, and molecular genetic features of the various nosological entities included in this new classification. These findings always have to be interpreted in the context of the clinical features and biologic behavior. Aim: To review the histological, phenotypical and molecular genetic features of the various nosological entities of the new WHO/EORTC classification for cutaneous lymphomas. Methods: Extensive review of the literature cited in Medline and own data of the authors. Results: The WHO/EORTC classification of cutaneous lymphomas comprises mature T‐cell and NK‐cell neoplasms, mature B‐cell neoplasms and immature hematopoietic malignancies. It reflects the unique features of primary cutaneous lymphoproliferative diseases. Conclusion: This classification is as much as possible compatible with the concept of the WHO classification for nodal lymphomas and the EORTC classification of cutaneous lymphomas. The histological, phenotypical and molecular genetic features always have to be interpreted in the context of the clinical features and biologic behavior.