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Osseous metaplasia in the setting of nephrogenic fibrosing dermopathy
Author(s) -
RuizGenao Diana P.,
PascualLopez Marta P.,
Fraga Savier,
Aragüés Maximiliano,
GarciaDiez Amaro
Publication year - 2005
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2005.00277.x
Subject(s) - medicine , pathology , dermis , metaplasia , nephrogenic systemic fibrosis , fibrosis , pathological , ossification , thickening , dermatology , magnetic resonance imaging , anatomy , radiology , chemistry , polymer science
Background: Nephrogenic fibrosing dermopathy (NFD) is a new skin‐fibrosing disorder associated with renal dysfunction. It is marked by the acute onset of induration involving the upper and lower limbs, and it is characterized by distinctive histopathologic findings. Methods: We report the case of a patient on hemodialysis who presented initially with the characteristic clinical and pathological features of NFD. The patient progressively developed painful hyperkeratotic spicules on both thighs and bone metaplasia was confirmed. Results: Histological studies were performed at different stages of the disease showing an evolution from the well‐known initial phase of NFD, characterized by thickening of the dermis, increased number of fibroblast‐like cells, and mucin deposits, to an end stage characterized by the presence of dermal ossification. Conclusions: We report the exceptional finding of bone metaplasia in the setting of a case of NFD.