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Pleural mesothelioma with cutaneous extension to chest wall scars
Author(s) -
Shieh Sherry,
Grassi Marcelle,
Schwarz James K.,
Cheney Richard T.
Publication year - 2004
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2004.00219.x
Subject(s) - medicine , mesothelioma , pathology , carcinoembryonic antigen , peritoneal mesothelioma , cytokeratin , angiosarcoma , calretinin , immunohistochemistry , cancer
Background: Cutaneous mesothelioma is rare but may occur following local surgical procedures for visceral mesothelioma or as a metastasis. Methods: A patient with pleural mesothelioma, who developed papules within chest wall scars, 14 and 15 months after pleural biopsy and thoracentesis, respectively, is reported. Results: Histopathology showed an epithelioid tumor forming tubulopapillary and glandular structures. The diagnosis of mesothelioma was confirmed with immunohistochemistry. Tumor cells stained characteristically for low‐molecular‐weight cytokeratins 5/6, calretinin, and vimentin and were negative for mucicarmine, carcinoembryonic antigen, thyroid transcription factor 1, prostate‐specific antigen, gross cystic disease fluid protein, S‐100, factor VIII, and CD31. Conclusions: Histologically, mesothelioma may resemble a primary adnexal neoplasm, metastatic adenocarcinoma, or angiosarcoma. Immunohistochemistry can clarify the diagnosis. Clinicians should be aware of the varied presentations of mesothelioma, as cutaneous presentations are becoming increasingly common.