z-logo
Premium
Linear nevus comedonicus with epidermolytic hyperkeratosis
Author(s) -
Schecter Amy K.,
Lester Brian,
Pan Teddy D.,
RobinsonBostom Leslie
Publication year - 2004
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2004.00206.x
Subject(s) - stratum granulosum , stratum spinosum , epidermolytic hyperkeratosis , pathology , hyperkeratosis , dermatology , biology , acanthosis , medicine , stratum corneum
Background:  Nevus comedonicus (NC) is rarely associated with the histopathologic pattern of follicular epidermolytic hyperkeratosis (EHK). We found eight cases reported. In one case, the condition was transmitted to the offspring in the form of generalized EHK. Methods:  We describe a case of linear NC with EHK in a 46‐year‐old woman. Results:  Histopathologic examination revealed the typical features of NC. Additionally, the follicular epithelial walls showed EHK with characteristic perinuclear vacuolization in the stratum spinosum and stratum granulosum and large, irregular keratohyalin granules in the granular cell layer. Conclusions:  The clinical and histopathologic features of this case are consistent with a diagnosis of linear NC with EHK. Lesions of NC suspected by clinical exam should be examined microscopically to look for features of EHK. If present, patients should be educated about the risk, albeit rare, of passing on a more severe form of the disorder to subsequent generations.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here